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زیست شناسی::
عامل رونویسی
Several studies have revealed that some neoblasts express different sets of transcription factors that correlate with specific cell fates in the planarian adult, which suggests that lineage specification of stem cell populations may exist in the organism for normal development and in response to injury (Hayashi et al. 2010; Pearson et al. 2010; Shibata et al. 2012).
These bile acids are received by the hepatocytes and activate the Fxr transcription factor, which promotes cell division.
Metamorphosis in all three groups is accomplished by lipid hormones that activate transcription factors.
T3 may regulate this change by inducing a set of transcription factors that specifically activates expression of the urea-cycle genes while suppressing the genes responsible for ammonia synthesis (Cohen 1970; Atkinson et al. 1996,1998).
Once inside the cell, T3 binds to the nuclear thyroid hormone receptors (TRs) with much higher affinity than does X,, and causes these transcription factors to become transcriptional activators of gene expression.
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2
عمومی::
فاکتور رونویسی
Attempts to inhib- it the inflammatory M1-like macrophage phenotype, including blocking activity of inflammatory cytokines and transcription factors involved in inducing this phenotype, have been investigated for the treatment of in- flammatory tissue diseases.
Finally, nanoparticle delivery of siRNA against the transcription factor in- sulin response factor (IRF)-5, which has been associated with the M1-like phenotype, reduced expression of inflammatory genes in macrophages, reduced protease activity and promoted the resolution of inflammation after myocardial infarction in mice, with reduced subsequent left ventric- ular dilation [81].
, In vivo silencing of the transcription factor IRF5 reprograms the macrophage pheno- type and improves infarct healing, J.
This signaling pathway activates the transcription factor, NF-κB, which leads to expression of pro-inflammatory genes.
Internal: HMOX-1 gene, activating found near hemmorrhaged vessels in atherosclerotic plaques; anti-inflammatory effects transcription factor (ATF) M4 CXCL4 derived macrophage - Surface: CD206, CD86, Lack CD163
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